Methylphenidate and Seizures

Methylphenidate improves learning impairments and hyperthermia-induced seizures caused by an Scn1a mutation.

OBJECTIVE Developmental disorders including cognitive deficit, hyperkinetic disorder, and autistic behaviors are frequently comorbid in epileptic patients with SCN1A mutations. However, the mechanisms underlying these developmental disorders are poorly understood and treatments are currently unavailable. Using a rodent model with an Scn1a mutation, we aimed to elucidate the pathophysiologic bas...

Methylphenidate and cognitive performance

Methylphenidate (MPH) is the active ingredient of stimulant drugs that are frequently prescribed to individuals with Attention Deficit / Hyperactivity Disorder (ADHD). In this chapter we examine the effect of MPH on different aspects of cognitive performance. The reviewed findings suggest that MPH effectively enhances sustained attention, response inhibition, and working memory capacities; yet ...

Methylphenidate use and divorce.

The findings in a CMAJ research article by Lisa Strohschein on methylphenidate use among Canadian children are likely to be misinterpreted because of the methodology used and the author’s interpretation of the data. Strohschein used survey data indicating whether divorce occurred in participating Canadian households at any point from 1994 to 2000 to categorize families as those in which the par...

Methylphenidate and its Enantiomers

Methylphenidate and Dyslipidemia

Methylphenidate is a piperidine derivative, structurally related to amphetamines and acts as a CNS stimulant. Methylphenidate has been widely used since 1937 for numerous indications including attention deficit hyperactivity disorder (ADHD), narcolepsy, cataplexy (3) and conduct disorder (4) in children and adolescents as well as adults (4). Although it has been indicated for ADHD since 1957 it...